The Prognostic Significance of ASXL1/EZH2 Co-Mutation in Comparison with ASXL1 or EZH2 Mutation Alone in Myelodysplastic Syndromes
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چکیده
منابع مشابه
Distinct mutation profile and prognostic relevance in patients with hypoplastic myelodysplastic syndromes (h-MDS)
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies. Although most MDS patients have normal or increased BM cellularity (NH-MDS), some have hypocellular BM (h-MDS). The reports concerning the differences in genetic alterations between h-MDS and NH-MDS patients are limited. In this study, 369 MDS patients diagnosed according to the WHO 2008 criteria were recruit...
متن کاملTET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).
Oncogenic pathways underlying in the development of myelodysplastic syndromes (MDS) remain poorly characterized, but mutations of the ten-eleven translocation 2 (TET2) gene are frequently observed. In the present work, we evaluated the prognostic impact of TET2 mutations in MDS. Frameshift, nonsense, missense mutations, or defects in gene structure were identified in 22 (22.9%) of 96 patients (...
متن کاملMYELOID NEOPLASIA TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
*Olivier Kosmider,1-5 *Véronique Gelsi-Boyer,6 Meyling Cheok,7,8 Sophie Grabar,5,9 Véronique Della-Valle,5,10 Françoise Picard,1,5 Franck Viguié,1,5 Bruno Quesnel,7,11 Odile Beyne-Rauzy,12 Eric Solary,13 Norbert Vey,14 Mathilde Hunault-Berger,15 Pierre Fenaux,16 Véronique Mansat-De Mas,17 Eric Delabesse,17 Philippe Guardiola,15 Catherine Lacombe,1-5 William Vainchenker,18 Claude Preudhomme,7,8 ...
متن کاملcomparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.
heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولPrognostic factors in myelodysplastic syndromes.
UNLABELLED BACKGROUND Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myel...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-132070